People with persistent smell deficits are more likely to develop brain imaging abnormalities suggestive of Parkinson’s disease, or be diagnosed with the disease, than those whose deficits return to normal on a subsequent smell test,
Parkinsons Articles
Study: RAGE Protein Plays Key Role in Parkinson’s Neuroinflammation
Scientists have shed new light on the interaction of toxic apha-synuclein clumps — a hallmark of Parkinson’s disease — with microglia, the brain’s immune cells. This interaction was found to be mediated by RAGE, a
Servier Licenses LRRK2 Inhibitor, Phase 1 Trial to Start by Year’s End
Servier is set to launch a Phase 1 clinical trial in healthy volunteers to investigate an LRRK2 inhibitor, developed in collaboration with Oncodesign, as a treatment for Parkinson’s disease. The trial, to start before the end
Survival With Parkinson’s Tied to Age at Onset, Cognition in Study
Older age at onset, a faster rate of disease progression, and severe cognitive impairment are key factors in poorer survival rates for people with Parkinson’s disease, a study that followed patients in northern China for 10
GT-02287 Helps Prevent Toxic Alpha-synuclein in Patient-derived Cells
GT-02287, Gain Therapeutics’ experimental oral therapy, reduced the toxic alpha-synuclein protein clumps that characterize Parkinson’s disease in lab-grown nerve cells derived from patients with disease-causing mutations in the GBA1 gene, the company announced. The treatment
Zonisamide for Epilepsy May Ease Parkinson’s Motor Symptoms: Study
Zonisamide, an epilepsy medication approved in the U.S. for some seizure-causing disorders, may reduce the motor symptoms of Parkinson’s disease, according to a review study of clinical trial data. The findings also suggest the therapy
Trial to Detect Alpha-Synuclein Deposits in Patients’ Eyes Underway
A Phase 1/2a clinical trial testing the ability of AMDX-2011P to safely detect abnormal protein deposits in the retina of adults with Parkinson’s disease and amyotrophic lateral sclerosis (ALS), possibly allowing earlier diagnosis and easier
Gold medal-winning paralympian new NDIA chair
Paralympian and disability advocate Kurt Fearnley appointed chair of the National Disability Insurance Agency. The post Gold medal-winning
At-home Gait Monitor May Track Progression, Treatment Response
Continuously monitoring the gait of Parkinson’s disease patients in their homes using a wireless device is feasible and may provide more sensitive measurements of disease progression and treatment response, according to a new study. The
How Parkinson’s Disease Spreads in the Brain Shown in Mouse Study
Clumps of alpha-synuclein protein, which build to toxic levels in the brain and spinal cord of Parkinson’s disease patients, spread via a cellular waste-ejection process, according to a study in mice. These clumps, which failed
MJFF and Edmond J. Safra Foundation Expand Network
The Michael J. Fox Foundation for Parkinson’s Research (MJFF) announced it will expand the number and reach of Parkinson’s disease clinician-researchers around the world, in partnership with the Edmond J. Safra Foundation. The Edmond J.
Oral GT-02287 Improves Fine Motor Skills in Mice
Gain Therapeutics’ GT-02287, an oral candidate therapy for Parkinson’s disease, led to dose-dependent improvements in the health of nerve cells and fine motor skills in mice. These findings, presented recently as a poster at the